HYPOXANTHINE UPTAKE BY ISOLATED BRAIN MICRO-VESSELS: 27
نویسندگان
چکیده
منابع مشابه
High-resolution imaging of vessels in the isolated rat brain
Introduction: While several atlases are available depicting the spatial distribution of various parameters either measured with MRI or from histological section, no comparable comprehensive data exists for the distribution of vessels in the rat brain. Angiography is able to use the blood flow in the brain of the living rat to display the largest arteries, while SWI can visualize veins down to m...
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Traumatic brain injury (TBI) is a significant public health concern in our country, because of placing in top three most common causes of death and substantial direct and indirect costs to society. The incidence of TBI in our country is 1.7 times of international incidence. Traumatic brain injury induced by primary and secondary mechanisms that give rise to death and neurologic morbidity in pat...
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In 1980, Furchgott and Zawadskil first showed that an intact endothelium must be present for acetylcholine to relax isolated vessels. This was subsequently found to be true for many other vasoactive substances.2-6 As a result of work from several laboratories, this response has been shown to occur because the endothelium releases a shortlived nonprostanoid compound or family of compounds collec...
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The effect of steroids on the uptake and release of K+ by capillaries isolated from rat brain was investigated. 86Rb’ uptake was used as a transport analog of K+. The uptake of 86Rb’ by the capillaries was markedly inhibited by ouabain. The ouabain sensitive fraction of 86Rb’ uptake was inhibited by corticosterone with an 150 of 8 X 10m4M. Inhibition was immediate in onset and rapidly reversibl...
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Astrocyte endfeet surround brain blood vessels and can play a role in the delivery of therapeutic drugs for Parkinson's disease. However, there is no previous evidence of the presence of LAT transporter for L-DOPA in brain astrocytes except in culture. Using systemic L-DOPA administration and a combination of patch clamp, histochemistry and confocal microscopy we found that L-DOPA is accumulate...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198507000-00047